AV and NGAV are not able to explicitly defend against Spectre and Meltdown vulnerabilities, but may be able to detect and stop malware that attempts to exploit these vulnerabilities.
Multi-layer security: To complement the protection against infections, such as NGAV, we recommend the use of functions to protect against infections, such as enSilo's Endpoint Security Agent. The enSilo software provides full transparency at kernel level on the endpoint and can detect malware threats that exploit Spectre and Meltdown vulnerabilities in real-time.
enSilo had early access to the Windows patch released by Microsoft on January 4, 2018 and had thoroughly tested it last month. No updates to the existing enSilo platform are required to be protected against attacks that exploit this vulnerability. Matrix42's Automated Endpoint Security by enSilo pre- and post-infection pre- and post-infection prevention features can fully protect against malware such as Spectre and Meltdown.